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In one other examine, male F rats were treated with three intraperitoneal injections of 3-methyl-. Based on the examine of Yeung et al.


Animals that died confirmed hyperaemia and distension of stomach and gut, while there were no gross lesions at necropsy in survivors Flickinger, In another study with CFY rats. Most of the studies are of sufficient quality and acceptable for danger characterization purposes.
As is well-known in dermal absorption studies, the nature of the car has a fantastic affect on the absorption of a compound. Resorcinol seems to be absorbed a lot better from anti-acne preparations than from the hair dye preparations underneath normal usage circumstances.
Two lengthy-time period studies with Swiss mice or NZW rabbits, where the animals were treated with 0. In an in vitro. In an investigation in three human volunteers using circumstances much like those utilized in hair dyeing, 14 C-ring-labelled 1. This means that only a small amount of resorcinol penetrates the skin in the course of the actual strategy of hair colouring.


There are differences in thyroid physiology between people and animals. The weight of evidence suggests that rodents are more sensitive to thyroid results than humans.





  • In follow, however, the incidence of sensitization appears to be low.




  • In most of the older studies, the effects of resorcinol exposure on the thyroid gland are conflicting.




  • It is therefore potential that these neurological results are because of the acute effect of the gavage administration.




  • There are differences in thyroid physiology between humans and animals.




  • For the benthic and terrestrial compartments, the obtainable toxicity data can't be thought to be adequate for a quantitative risk characterization.





Fifty per cent of survivors were sacrificed 1 week later, and blood and urine samples have been taken. Resorcinol confirmed a focus-dependent increase in labelling index [ three H]thymidine , acanthosis, and papillomatosis. After application of an ointment containing To study the goitrogenic activity of resorcinol, female Wistar rats were treated twice day by day for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.

Hence, an improved biodegradation rate results in lowered dangers for the environment. Regarding the consequences of resorcinol on aquatic species, the toxicity knowledge set includes a wide range of species from different trophic levels. Results from exams with totally different aquatic species from totally different trophic ranges can be found for the acute toxicity of resorcinol to aquatic organisms.
In both species, there have been no antagonistic effects on ultimate mean physique weights, haematology, or medical chemistry parameters, and no chemical-related gross or microscopic lesions have been observed. In another research, rats had been uncovered to 0 or zero. No thyroid hormone measurements had been carried out.
The third examine, performed in , included of energetic staff. In subjects men, 13 women with a mean age of 37 years, each laboratory and different tests, together with medical examination, have been done; no irregular thyroid glands or modifications in T 4 values had been present in any of the themes compared with regular values Bauer, The above data are restricted as a result of small study sizes, lack of comparability groups, missing present and historic control knowledge, and missing information concerning potential publicity classes. In a research in a plant producing resorcinol by sulfonation of benzene — and in addition producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — staff were exposed primarily to resorcinol, but the exposure to other brokers was not measured for publicity ranges, see part 6. In this plant, three cross-sectional research have been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary operate, haematology, and medical chemistry had been carried out with of persons actively employed at a production plant in Pennsylvania, USA. In addition, male rats have larger circulating ranges of TSH than females.


The organisms had been uncovered to the take a look at concentrations for 96 h. Biological observations were carried out day by day.
In basic, the h LC 50 values for resorcinol had been in the range between In move-through exams and analytical monitoring, DeGraeve et al. As talked about in part 9. Complete therapeutic was famous after about 1 week of absence from work. However, with growing resorcinol concentrations, there was additionally an increase in the number of persons who examined optimistic. Resorcinol was additionally examined in hairdressers, who may have been involved with resorcinol-containing hair dyes.